HPV16-18、HSP70、p53、c-myc與宮頸癌的相關(guān)性研究.pdf

1、青島大學(xué)碩士學(xué)位論文HPV1618、HSP70、p53、cmyc與宮頸癌的相關(guān)性研究姓名：孫選申請學(xué)位級別：碩士專業(yè)：婦產(chǎn)科學(xué)指導(dǎo)教師：戴淑真20050528英文摘要TherelationshipamongHPVl6／18、HSPT0、p53、cmycandcervicalcancerABSTRACTObstracfivcTounderstandtheinfectionofHPVl6／18，andtheexpressionofHSP70

2、，P53，andc—mycproteinincancerinsitu(CIS)，cervicalearcinomas(CC)andnormalcervicaltissuesToanalysethepotentialpathogenicroleofHPV16／18infectionandHSP70，P53andcmycproteininoncogenesisanddevelopmentofcervicalcancersToexploret

3、herelationshipamongHSP70，P53andc—mycindevelopmentofcervicalcancerMethodsHPVl6／18DNAwastestedinCINⅡIcervicalcarcinomasandnormalcervicaltissuesbyPCRandtheexpressionofHSP70，P53andcmycproteinwasexaminedbyimmunohistoehemistry

4、methodrespectivelyResults①TheinfectionrateofHPVl6／18inCISandCCwashigherthaninnormalcervicaltissue；statisticallytherewasnodifferencebetweenCISandCC@TheexpressionofHSP70proteininHPVDNApositivegroupisgreaterthaninHPVDNAnega

5、tivegroup；TheexpressionofHSP70proteininCCandCISisgreaterthaninnormalcervicaltissue⑨TheexpressionofP53proteininHPVDNAnegativegroupisgreaterthaninHPVoDNApositivegroup；TheexpressionofP53proteininCCandCISisgreaterthaninnorma

6、lcervicaltissue(g)TheexpressionofcmycproteininCCandCISisgreaterthaninnormalcervicaltissue⑤TherewaspositivecorrelationbetweenHSP70andP53proteinexpressionandpositivecorrelationbetweenHSP70andc—mycproteinexpressionTherewasn

7、orelationshinbetweenP53andc—mycproteinexpressionConclusion①TheinfectionofHPVl6／18iscloselyrelatedtooncogenesisofcervicalcancer售)HSP70isoverxpressioninCC③HSP70actasamolecularchaperonestostableP53andc—mycproteinKeywords：ce