立克寧腸溶微丸的制備工藝及質(zhì)量標(biāo)準(zhǔn)的初步研究.pdf

1、黑龍江中醫(yī)藥大學(xué)碩士學(xué)位論文立克寧腸溶微丸的制備工藝及質(zhì)量標(biāo)準(zhǔn)的初步研究姓名：王曉輝申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：藥劑學(xué)指導(dǎo)教師：李永吉20060501黑尼江中醫(yī)藥人學(xué)碩1學(xué)位論史ABSTRACTIntestinaltractinfbctiousdiseasesbreakoutwidelyandhavemanvcomplicationsItnotonlydoesgreatharmtopeople’shealthandlife，butalsoa

2、ff色ctpeople’sproductionandworkCurrentlythedosagefbrmsofthetreatingdrugareordinaryoraltablet，suppository，clysterandsoonHoweVer，thesedosagefbrmshaveshortages，suchasusedinconVenience，theefficacyisnotideal，relapserateishigha

3、ndnumberofadversereactionsismore三f七已玎f“gintestinalpeetsisamodernChinesemedicinepreparationwhichhasantiseDticandantiviralcurativeeffects，withnoreleaseinthestomachandpositioningreleaseinintestineSothatthedrugcanpr010ngandi

4、mproVepharmacodynamicactionduetohighdenseinintestineInthebasisofpreliminarystudies，thisstudyincIudesshapingtechnology，coatingtechnologyandprimaryqualitystandardsstudyfor三砒e“f“gintestinalpelIetThisstudypreparedpelletcores

5、withextrusionspheronizationmethod，aftertheprescriptionfactorandthetechnoJogyfactorinspected，wedetermined上f七P船f’曙intestinalpe】1etsthepreparationtechnology，bywhichweobtainedpaniclesize10～18meshpelletsreceivingrateabove75％，

6、theresultisquiteideal_ThemethodofreVolvingpotcoatingcontainspillcorebyintestinaImate“alsThesingIefactorinspectionhasestablishedthecoatingtechnologyAcrylicacidresinTI，111wasthemainthinfilmcoatingmaterial，thecoatingpelletr

7、ateoffinishedproductswashigh，finishedproducecanachieVeattheintestinesdepartmentreIeaserequestbydissoIvedeterminationinVitroAtthesametimethe置yrj，2舒，把msf沈wasqualitativeinVestigationbythethin1ayerchromatographyandquantitati