強迫癥動物模型建立及針刺干預(yù)的實驗研究.pdf

1、遼寧中醫(yī)藥大學碩士學位論文強迫癥動物模型建立及針刺干預(yù)的實驗研究姓名：劉家峰申請學位級別：碩士專業(yè)：針灸推拿學指導教師：任路20080410AbstractAim：Thisstudybyavoidingexperiments，damagetothebasalganglia，dopamineagonistinjectionestablishedratmodelofobsessive—compulSiredisorder，observati

2、onofbehaviorchange，thecentralserotoninanddopamineneurotransmitteractivity，andtostudyacupunctureOnthetreatmentofobsessive—compulsivedisorderonthetreatmentmechanismMethods：70healthyadultmaleratsthroughsurgerySDmodel，step—t

3、hroughmodel，dopamineagonists(QNP)modelofthesethreemethodsestablishedratmodelofobsessive—compulsivedisorder，andweredividedintosevengroups：：controlgroup，Operationgroup，surgeryandacupuncturegroup，avoidinggroupsandavoiddark—

4、plusgroup，QNPgroup，QNP—plusgroupE1ectroacupuncture”100”green”Yintang’Pointafterthebehaviortestafterdeath，usinghigh—performance1iquid—electrochemicaldetectionofthecentralsystemofserotonin(5一HT)anddopamine(DA)FortestingRes

5、ults：Model，thetwogroupsofratstoreturnhomefrequency，andthetotaldistancemovementwassignificantlymorethantheblank，visitthesitesteduce，reducethetimeteturnhomeCentralnervoussystem5一HTgrouphigherthannormal1evel，DRlevelsincreas

6、ed(尸O05)，electro—acupunctureintervention，5一HT，DAinamodelgrouphasdeclinedConclusions：1Thisstudyobservedthattheratsbyavoidingsurgerymodel，dopamineagonistmodelbehaviorafterthechangesinthebrain5一HTtransmitterwasincreased，DRa

7、ctivitywassignificantlyincreasedRatsavoidingexperiment，dopamineagonistmodelandtheoperationmodelisabetteranimalmodelofOCD2AcupuncturecanimprovetheOCDofthechangesinbehaviour，reducingOCDratbrain5一HTactivity，reducingDRconten