首發(fā)腦小血管閉塞性卒中患者早期認知功能評價.pdf

1、分類號R74ICS學校代碼10136學號201200136委：￡≈莖一3家名民慶大學首發(fā)腦小血管閉塞性卒中患者早期認知功能評價EvaluationofCognitiveFunctiononPatientswithFirstEpisodeofSmallVesselOcclusiveStrokeinTheirEarlyStage申請人：金花學科專業(yè)：臨床醫(yī)學研究方向：神經病學學位類別：專業(yè)學位指導教師i張東威論文提交日期：二。一五年五月Ab

2、stractObjective：Thispaperistoevaluatecognitivefunctionofthefirstepisodeofsmall—vesselocclusivestrokepatientsbymeansofMiniMentalStateExamination(MMSE】andMontrealCongitiveAssessment(MoCA)Also，thesensibilityandspecificityof

3、MMSEwerecomparedwithMoCAforassessingcognitivedysfunctionofthefirstepisodeofsmall。vesselocclusivestrokepatientsintheirearlystageinthispaperThebestcutoffpointforevaluationofthecognitivedysfunctionofthefrrsVepisodeofsmallve

4、sselocclusivestrokepatientsintheirearlystageisdeterminedbymaximumYoudenindexMethod：Atotal100casesofpatientgroupwhichwasdiagnosedasthefirstepisodeofsmallvesselocclusivestroke。andmatchestheinclusionandexclusionStandardcoll

5、ected—fromtheinpatientandoutpatientinneurologydepartmentofAffiliatedHospitalofInnerMongoliaUniversityforNationalities，duringNovember2013tONovember2014Inthemeantime，wetake100healthysubjectsfromtheinpatientandoutpatientwho

6、matchthecontrolstandardandpassthephysicalexaminationThenwecollectedtheirclinicaldataandwealsodidneuropsychologicalevaluationamong2groupsResults：1TheMoCAscoresweresignificantlylowerinpatimtsgroup衄thenamalgroup(2099士422vs2

7、7154136)!菡、砌aSlkMMSE儺(2587士321vs27294220)ThepatientgroupjSscoresofeverycognitivemeasureinMoCAscaleweresignificantlylowerthanthatthecontrolgroupespeciallyinthesethreeaspectsofvisuospatialexecutivefunction，attentionanddela

8、yedmemoryrecall@005)，alsothepatientgroup’SscoresofeverycognitivemeasureinMMSEscaleweresignificantlylowerthanthatthecontrolgroupinthememoryrecallp005)2ThebestclinicalcutoffpointoftheMMSEtestforthefirstepisodeofsmallvessel

9、occlusivestrokepatients‘earlycognitivedysfunctionwas25／26，whichwasprimarilydeterminedbyreceiveroperatingcharacteristicandthemaximumYoudenindexWith25／26asthecutoffpointthesensibilityandspecificityofMoCAscaleissignificantl

10、yhigherthantheMMSEscale(With26／27asthecutoffpoint，thesensibilityis73％，andthespecificityis50％)toevaluatethefirstepisodeofsmallvesselocclusivestrokepatients’earl)cognitivedysfunction，thesensibilityis93％forMoCAtest，andthesp

11、ecificityis87％3TheMMSEandMoCAscoresweredifferfrompatients’educmionlevelsForthepatientgroup，theMoCAandMMSEscoresofthosewhogotthemiddleschoolandtheaboveeducmionweresignificantlyhigherthanthosewhoreceivedundermiddleschooled