山西省非綜合征性唇腭裂影響因素病例對照研究.pdf

1、山西醫(yī)科大學(xué)碩士學(xué)位論文山西省非綜合征性唇腭裂影響因素病例對照研究姓名：馬艷春申請學(xué)位級別：碩士專業(yè)：流行病與衛(wèi)生統(tǒng)計學(xué)指導(dǎo)教師：曲成毅20080515山西醫(yī)科大學(xué)碩士學(xué)位論文ACasecontrolStudyofNon—syndromicCleftLipandPalateinShanxiProvinceAbstractObjective：ToinvestigatethesituationofnonsyndromicCleftLipan

2、dPalateinShanxiprovincefrom1997tO2006andanalysethepossibleriskfactorsToprovidethescientificbasisforpreventingmethodsMethods：ThestudycontainstwopartsThefirstpartisdescriptivestudyTocollectthedateofmCLPin33hospitalsinShanx

3、iprovincefrom1997to2006andanalysethechangetrendofnsCLPintenyearsbytrendchi—squaretestnesecondpartiscase—controlstudyWedesignthequestionairandselect100mCLPmothersasacasegroupand200mothers塒thnormalnewbornsasacontrolgroupby

4、1：2fromJan2005toDec2006The25factorsweinvestigatewereanalysedonebyone、析t11univariatelogisticandthosethathavemeaninginstatisticswerefurtheranalysed硒mCoxregressionResultsThetotalineidenceofnsCLPinShanxiwasl946／10000Therewas

5、nosignificantlychangetrendintenyearsTheincidenceofmCLPinruralareasissignificantlyhigherthanthatinurbanareas，higherinmalethaninfemalebirthsUnivariateelogisticregressionshowedthatpermanentresidence，educationdegree，familyhi

6、storysystemicdiseases，earlypregnancyfluearlypregnancydrug，passivesmokingandbirthweighthavemeaninginstatistics(PO05)ThosefactorswereanalysedfurtherbyCoxregressionandfamilyhistoryearlypregnancydrug，passivesmoking，birthweig

7、htareconsideredriskfactors，ORvaluesare15512(95％CIforOR：2276105766)、2766(95％CIforOR：14065441)、3011(95％CIforOR：1533—5914)、2608(95％CIforOR：12755332)respectivelyandeducationdegreeispreventfactors，ORvaluesis0264(95％CIforOR：O1

8、390499)。Conclusion功eincidenceofnsCLPinShanxiwashigherthanotherprovinceinchinaandnosignificantlydeclinetrendinincidenceofnsCLPWaSobservedduring1997—2006Familyhistoryearlypregnancydrug，passivesmokingandbirthweightageriskfa