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1、山西醫(yī)科大學(xué)碩士學(xué)位論文卵巢顆粒細(xì)胞瘤中WT1蛋白、AMH和Ki67的表達(dá)及其意義的研究姓名:張盈盈申請(qǐng)學(xué)位級(jí)別:碩士專業(yè):病理學(xué)與病理生理學(xué)指導(dǎo)教師:姚漢武20090315西醫(yī)科大學(xué)碩十學(xué)位論文ExpressionofWT1proteinAMHandKi一67inovariangranulosacelltumourandthesignificanceAbstractObjective:Todetecttheexpressionof、秤

2、1protein,Anti—MullerianHormoneandKi一67inovariangranulosacelltumourAndtoexploretheexpressionofWT1proteinandAntiMullerianHormoneinthedevelopmentofovariangranulosacelltumourandtherelationshipbetweenthemToexploretheroleofWT1

3、proteinandAnti—MullerianHormoneinthedevelopmentofovariangranulosacelltumourandtostudytherelationshipbetweentheexpressionofthemandthebionomicsofovariangranulosacelltumourBesides,wetrytoexplorethevalueoftumoursdifferentiat

4、ioninpredictingtheprognosisofovarianGeTMethods:37casesoftheovariangranulosacelltumourand10casesofnormalovaryweredetectedonTissueMicroarries,theexpressionofW,T1protein,AMHandKi67wasmeasuredwithlmmunohistchemistryTheresult

5、swereanalyzedwithSPSS11,5statisticalsoftwareResults:①hthenormalovaryeveryindexonlyexpressingranulosacellsofprimaryfolliclesandsecondaryfollicles,buthasnoexpressionintheprimitiveandmaturefolliclesTheratiosofhypo—expressio

6、nofWT1proteinandAMHbetweentheprimaryfolliclesandthesecondaryfolliclesweresignificantlydifferent(P005)TheratiosofexpressionofWT1proteinandAMHinovariangranulosacelltumourare811%and784%②Theratiosofhypo—expressionofWT1protei

7、nandAMHintherecrudescentpatientsandthepatientswithasciteswerelowerthanthatintheunrecrudescentpatientsandthepatientswithoutofascites,andthedifferencehasstatisticalsignificance(P/3/10HPFandthetumourswithconspicuousheteromo

8、rphismofcellswerelowerthanthatintumoursofwhichthehistotypeisn’tasystematic,inthecasesofcaryocinesis3/10HPFandthetumourswithoutofconspicuousheteromorphismofcells,andthedifferencehasstatisticalsignificance(P005)Theprolifer

9、ationindexofKi一67werealsoconcemedwiththetumourshistotype,thetumourcells’caryocinesisandheteromorphism(P005)③TheratiosofpositiveexpressionofWT1proteinandAMHinstage1werehigherthanthatinstageIIandstageIII(PO01)Theproliferat

10、ionindexofKi67wasalsoconcernedwiththeclinicalstage(P001)@Thetumourshistotype,thetumourcells’caryocinesisandheteromorphismwereconcernedwiththetumoursrecidivationandclinicalstageInthepatientsofstageI,theratiooftherecrudesc

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