妊娠高血壓綜合征患者ADM和AngⅡ的變化及臨床意義.pdf

1、山西醫(yī)科大學碩士學位論文妊娠高血壓綜合征患者ADM和AngⅡ的變化及臨床意義姓名：徐波申請學位級別：碩士專業(yè)：婦產(chǎn)科學指導(dǎo)教師：成要平20040512“I西醫(yī)科大學碩上學位論文ThechangeandclinicalsignificanceofAdrenomedullinandAngiotensionIIinPatientswithPregnancy—inducedHypertensionSyndromeAbstractobjectiv

2、e：Toinvestigatethecontentofadrenomedullin(ADM)andAngiotensionlI(AngII)inpatientswithPregnancyinducedHypertensionSyndrome(PIH)，andnormallatepregnantwomanandnotpregnantwoman，inordertesearchthepathogenesisandclinicalsignifi

3、canceoftheP1HMethods：1、Tomeasuredbyradiommunoassay：①TheplasmaADMandAnglIlevelsinPIH、normallatepregnantwomanandnotpregnantwoman②TohaveusedtheLigustraziniinapartofplasmaADMandAnglIlevelsinP1H2、TheADMandAnglIinplacentawered

4、eterminedbyimmunohistochemistrymethodwithPIHandnormalpregnantwomanResult：1、TheplasmalevelsofADMinPIHgroupsweresignificantlyhigherinpatientswithnormalpregnantwomangroups，TheplasmaADMandAnglIinPIHgroupsandnormalpregnantwom

5、angroupshavenotablemeaningTheplasmaADMandAngllinPIH：severemoderatemildPIHgroupsThereweresignificantlydifferenceinthreegroups(p005)2、TheuseofLigustraziniinpatientswithPIHwerenotablemeaningdecreasedfrombeginningtoendbetwee

6、nplasmaADMandAnglIOO05)3、NotpregnantwomengroupsandnormalpregnantwomengroupsinplasmaADMandAngnhavenotablemeaning0005)4、TheADMmadAngllwereexpressedinbothnormalandPIHplacentaHowever，itslevelwassignificantlyhigherinthelatter

7、thanintheformerTheADMandAngIlwerelocatedinvascularendotheliumandsyncytiotrophoblastofplacentaThenormalpregnancygroupsandPIHgroupsandwerenotableconditionwithPIH0005)，theexpresswerestrengtheninplacenta5、Thetwogroupsofnorma