磁性鐵氧體納米顆粒及其相關結構的調控制備.pdf

1、東南大學碩士學位論文磁性鐵氧體納米顆粒及其相關結構的調控制備姓名：孫永康申請學位級別：碩士專業(yè)：生物醫(yī)學工程指導教師：顧寧張宇20040601受主蘭苧!壁絲壁墨堡墅鲞壁塾墨苧塑莖墮塑墮塑絲型量————————————一AbstractTheresearchbackgroundofthispaperisbasedonthepreparationofmagneticmaterialsfortumourtherapybymagneticflu

2、idhyperthermia(MFH)Thematerialsinthisapplicationarerequiredtobebiocompatible，ofwhichtheFe304、Fe203withlowbiotoxicityarerationalcandidatesAtthesametimetheheatingabilityoftheironoxidenanoparticlesisduetothesynthesisroutean

3、disdirectlyrelatedwiththeefficiencyofthetherapySoatunablesynthesisrouteofironoxidenanoparticlesisnecessaryFurtheraresearchofthetunablesynthesisandthedevelopmentofrelatedironoxidenanostructuresareofimportancetotheresearch

4、ofMFHtherapyFirstlyaerationbubblingoxidizafionofacidifiedFes04nanoparticlessuspensionpreparedwithcoprecipitationmethodat90oCisusedtosynthesisyFe203nanoparticles，whichnearlyhavethesameheatingabilitywiththeFe304onesAfterth

5、is，theeffectsofinitialexperimentalconditions，suchastheratioofFe3、Fe2，reactiontimeandreactionvolume，onthefinalproductsarestudiedTheresultsshowthatthesizeCallbetunedin14m一30mnSubsequentlytheheatingabilityoftheFe304nanopart

6、iclescanbealteredduetothesizedifferencesBasedontheseresultsstablewaterdispersedmagneticfluidisobtainedwitllglutamicacidmodifying17nmTFe203nanoparticlesandcanbeusedfortheMFHtumortherapySecondlypurifiedoleicacidisusedtomod

7、ifytheFe304nanoparticlesbycoprecipitationmethodandyFe203byaerationbubblingoxidizationmethodMagneticfluidofnonpolarorganicdispersantisobtmnedandthechelatingstructuresofoleicacidonironoxidesurfaceareconfirmedtobebidentatea

8、ndoleate—bridgebiodentateconfigurationsAtthesametime，ionicmagneticfluidispreparedbymodifying7nnlFe304nanoparticlesproducedbyreductioncoprecipitationmethodFe304@Si02core—shellnanostmcturesareobtainedbytheconventionalSt6be

9、rpolycondensationwithdilutesilicatesolutiontreatmentdirectlyinethan01FurthermorethethicknessofthesilicashellandthestabilityincreasewiththeamountofTEOSAsto18n／nFe304nanoparticles，magneticdipolechainsencapsulatedwithsilica