難治性癲癇患者外周血中MRP1表達(dá)的研究.pdf

1、青島大學(xué)碩士學(xué)位論文難治性癲癇患者外周血中MRP1表達(dá)的研究姓名：馬騰申請學(xué)位級(jí)別：碩士專業(yè)：神經(jīng)病學(xué)指導(dǎo)教師：譚蘭20050529ThestudyoftheexpressionofMRPlgeneinrefractoryepilepsyAbstractObjective：ToinvestigatetheexpressionofMRPlgeneintheperipheralbloodofrefractoryepilepsypatient

2、sanddiscussitssignificanceMaterialsandmethods：Thepatientsweredividedinto4groups：refractory印il印sy(GroupA)，epilepsyundercontrolbYantiepilepticdrugs㈣s)(CroupB)，epilepsywithoutAEDs(Groupc)andhealthadults(GroupDlTheexpression

3、ofMRPlintheirperipheralbloodcellswasdetectedbysemiquantitativereversetranscriptlonpolymerasechainreaction(RTVCR)Results：TheexpressionsofMRPlinthefourgroupsamallpositiveBysemiquantitativeRTPC＆wedetectedthatthemeanrelative

4、expressionofMRPlmRNAinthepedphera]bloodofrefractoryepilepsypatients(GroupA)was0776_0016andthatinGroupB，CandDwererespectively0627100090642_0010and0625_0006AnalyzedbyonewayANOVAitmeantthattheexpressionofMRPlmRNAintheperiph

5、eralbloodcellsofrefractoryepilepsypatientswasmuchhigherthanthatofthepatientsinothergroupandthedifferencewasofsignificancefP005)Conclusion：MRPlgenemayphyanimportantrole組themultipledrugresistance0∞R)ofrefractoryepilepsyHow

6、everontydruginductionorseizureitselfmaynotresuitinupregulationofMRPlexpressinnintheperipheralbloodPostgraduaIcstudent：TengMa(Neurology)DirectedbyProfLanTanKeywords：refractoryepilepsy；multipledrugresistance；multidrugprote