羧甲基殼聚糖-鈣鹽復(fù)合物誘導(dǎo)齒槽骨再生的實(shí)驗(yàn)研究.pdf

1、青島大學(xué)碩士學(xué)位論文羧甲基殼聚糖鈣鹽復(fù)合物誘導(dǎo)齒槽骨再生的實(shí)驗(yàn)研究姓名：朱淑云申請學(xué)位級別：碩士專業(yè)：口腔臨床醫(yī)學(xué)指導(dǎo)教師：張廣耘20060513TheExperimentalResearchofAlveolarBoneRegeneratedbyCompoundMaterialofCarboxymethylChitosanTricalciumPhosphateAbstraetObjective：Toobservetheresultsof

2、repairingalveolarbonedefectwiththebiologicalmaterialbysinglYusingofcarboxymethylchitosanortricalciUmphosphateorcompoundmaterialoftheaboveorBioosswhichc∞induceosteogenesisAndtoprovideexperimentalbasisforsearchingforthemor

3、eidealguidedtissueregeneration(GTR)materialMaterialsandmethods：30NewZealandrabbitswerechosenanddividedinto5groupsinrandomInGroupA，theblankcontrolonethemucoperiostealflapWassutureddirectlyaftertheanimalmodelofperiodontald

4、iseaseWaSfabricatedInGroupB，carboxymethylchitosanwasputintothebonedefectamaInGroupC，tricalciumphosphateWaSusedsinglyInGroupD，thesubstanceinGroupBandCWasmixedandusedAndinGroupE，BioOSSWasusedTheserabbitswerekilledatpostope

5、rative4weeks8weeks，and12weeksrespectivelyTheosteogenesiseffectWasstudiedbyXmyhistopathologyandimageanalysisResults：TheradiographsshowthattheboundarybetweentheoperativeareaandnormalareaisclearinGroupA，alittledimmerinGroup

6、BandC，andnotclearinGroupDandETheradiopacityattheboundaryisnotobviousinGroupA，alittlebetterinGroupBandC，andobviousinGroupDandEinwhichscatteredparticlesappearsclearThetissuesectionimagesshowthatboneisgeneratedinGroupB，C，Da

7、ndEcomparedwithGroupAandamongthelatter4groups，theosteogenesiseffectofGrouPDandEisbetterByimageandstatisticalanalysis，thedifferencebetweeneach2groupsissignificantwithP005Conclusion：Theinductionofosteogenesiseffectofthecom

8、poundmaterialofcarboxymethylchitosanandtricalciumphosphateandBioossissimilarEachhasartidealbioeompatibilityacheappriceandabrightprospectinclinicGraduatestudent：DirectedbyProfShuyunZhuGuangyunZhangKeywords：earboxymdthylch