2023年全國碩士研究生考試考研英語一試題真題(含答案詳解+作文范文)_第1頁
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1、青島大學(xué)碩士學(xué)位論文RAGE基因Gly82Ser多態(tài)性與腦梗死相關(guān)性研究姓名:高思山申請學(xué)位級別:碩士專業(yè):病理生理學(xué)指導(dǎo)教師:崔瑞耀2003.3.12英文摘要ASTUDYONTHEASSOCIATIONOFRAGEGENEGLY82SERPOLYMORPHISMINCERE—BRALINFARCTIONPATIENTSABSTRACTBackgroundCerebrovasculardiseaseisacommondiseasewit

2、hhighprevalencefre—quencyandhighmortalityItisoneofthethreemostdangerousdiseasesthatdangerpeople’shealthAlotofcorrelationfactorsstudied,hypertension,heatdisease,diabetesmellitus,smokingandalcoholarefoundasriskfactorsbyexp

3、ertshomeandabroadThoughpeoplehavestudiedandpreventedfaetorstheriskofmaincerebrovasculardis—ease,thatisbraininfarction,thereisastillahighprevalencefrequencyofbraininfarctionStudyingthereasonsofdiabetesmellituswithcerebral

4、infarction,hypertensionwitheere—bralinfarctionandcerebralinfarctiononly,especillystudyingthereasonsofgenemota—tion,whichisastrikingsignifianceObjectiveTostudytheassociationofRAGEgeneGly82Serpolymorphisminpatientswithcere

5、bralinfarctionaccordingtomultiplefactorsandmultiplegenesleadingtodiseaseMethodsFastingvenousbloodwasobtainedandbloodtotalgenomicDNAwasex—tractedTheGly82SergeneatpositionofRAGEgeneexon3wasdeterminedbyPCR—RFLPmethodin56typ

6、e2diabetesmellituspatientswithcerebralinfarction(DM&CI)60hypertensionwithcerebralinfarctionpatients(HP&CI),46cerebralinfarctionpatientsa—lone(e1)and50healthycontrolsubjectsofHannationalitybloodglucose,triglyeeride,choles

7、terolandelectrocardiogramareanalysed,diabeticmellitushistoryandhypertensionfamilyhistoryarewritedasstastisticsResultsThefrequenciesofRAGEgeneG1y82SerGSheterozygousgenotypeweresignificantlyhigherinhypertensionpatientswith

8、cerebralinfarctionthanthoseincontrolsubjects(P005)Inthemeantime,thestudyalsohasshownthathyper—tension,diabetesmellitus,heartdisease,diabeticmellitushistoryandhypertensionfamilyhistoryarestrongassociationwithcerebralinfar

9、ctionpatients(PO05)ConclusionRAGEgeneGly82SerGSheterozygousgenotypemaybeassociatedwithHP&CIpatientsRAGEgeneGly82SerpolymorphismisnotassociatedwithDM&CIandCIalonepatientsHypertension,diabetesmellitus,heartdisease,diabetie

10、mellitushistorvandhypertensionfamilyhistoryareriskfactorsofcerebralinfarction(P005)KEYWORDS:RAGEGiy82Sergene;cerebralinfarctiondiabetemellRusIhyperten—sion;polymorphismPostgraduate:GAOSishan(Pathophysiology)Directedby:CU

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