骨橋蛋白及其受體CD44v6在腎透明細胞癌中的表達及意義.pdf

1、中南大學碩士學位論文骨橋蛋白及其受體CD44v6在腎透明細胞癌中的表達及意義姓名：蒲友敏申請學位級別：碩士專業(yè)：外科學（泌尿外科）指導教師：蔣先鎮(zhèn)20070501碩七學位論文英文摘要AbstractOjectiveInordertosearchforareliableclinicalindicatorusedtoearlydiagnoseclearcellrenalsellcarcinoma(CCRCC)andtojudgethepro

2、gnosisofit，wetriedtoexploretheexpressionofOPNandCD44v6intheCCRCC，theirclinicalvalueandpossiblemechanismMethodsImmunohistochemicalmethodwasusedindetectingtheexpressionsof0PNandCD44v6in30CCRCCand10noncarcinomareflaltissues

3、ThediversitiesofexpressionsofOPNandCD44v6betweennoncarcinomaandCCRCCtissuesandamongvariOUSclinicalstagesandhistologicalgradeswerecloselystudiedtherelevancesofOPNandCD44v6werealsoanalyzedtoexploretheirpossiblemechanismsRe

4、suitsTheaverageareadensityofexpressionsofOPNinnoncarcinomatissueswas00012370000083481andinCCRCCwas00123903_001104629P005theexpressionsofOPNinCCRCCwereobviouslyhigherthaninnon—carcinomatissues；Theaverageareadensityofexpre

5、ssionsofCD44v6innoncarcinomatissueswas00022550_000206691andinCCRCCwas00291290002548064，P005theexpressionsofCD44v6inCCRCCwerealsoobviouslyhigherthaninnoncarcinomatissuesThereweresignificantdifferenceseintheexpressionsofOP

6、NamongtheCCRCCofvarioushistologicalgradesP=0042005，andtheexpressionsof0PNiIlhi曲gradewashigherthanitinlowgrade；ThereweresignificantdifierenceseintheexpressionsofCD44v6amongtheCCRCCofvariousclinicalstagesP=0034005andtheexp

7、ressionsofCD44v6inhighstagewashigherthanitinlowstageTherewassignificantpositivecorrelationbetweentheexpressionsof0PNandCD44v6inCCRCCtissues，P=0046005ConclusionsTheexpressionsofOPNandCD44v6inCCRCCwereobviouslyhigherthanin

8、non—carcinomatissues，topart，theirwerecorrelatedtovarioushistologicalgradesanddifferentclinicalstages；ThereWassignificantpositivecorrelationbetweentheexpressionsofOPNandCD44v6inCCRCCtissuesOPNupregulatedtheexpressionsofit