音樂(lè)和慢性應(yīng)激對(duì)大鼠神經(jīng)內(nèi)分泌、免疫及心理行為的影響.pdf

1、山西醫(yī)科大學(xué)碩士學(xué)位論文音樂(lè)和慢性應(yīng)激對(duì)大鼠神經(jīng)內(nèi)分泌、免疫及心理行為的影響姓名：馬麗琴申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：應(yīng)用心理學(xué)指導(dǎo)教師：盧莉20100609山西醫(yī)科大學(xué)碩士學(xué)位論文Theeffectsofmusiconratsofchronicpsychologicalst]ressinbehaVior，i舢munologicalfunctionandneuroimmunoendocrineAbstractobjectiVe：111isst

2、udyadopteddlronicpsycholo百calstressmodelinordertoobservethee日’ectofmusica11dc11onicpsycholo百calsnessonch鋤geofmoodandbehaViors，鋤d劬ctionofle鋤ing，鋤d‰ctionofmenlor)，alldreco印ition，aIldimmunolo西calf11Ilction，IL1p、IL一2、CORT、AC

3、TH、5HTinratnisVe巧importantthatⅡleuseSofmedica】curea11dint溯1ti明iIlsIlbhealth，andincreasethesmJctIlreofh啪anbeingMethods：向nymaleSDmtswerer孤domlydividedintocontrolgroup，psycholo百cals仃ess黟‘oup，musicexposed圈0up，s仃essplusmusice

4、xposed孕oup(n=10iIleachgroup)TheratmodeofstIessw部madebyperday’21daySnlllllingopeIlfieId，Morriswatermaze鋤dsuspeIldtailtestwerep吲eb徹edonch鋤geofmoodalldbehaViors，鋤d如nctionofleanlin呂andfhnctionofmemoryandrecog面tioninratThethy

5、musindexandspleenindex，theweightofmesent甜clymphoc”enode’ELISAw弱鋤ployedtomeasurelevelsofimerleukine1(IL1)鋤dim盯leukine一2(IL一2)RIAw鶴鋤ployedt0measureleVelsofconicosterone(CoI江)andadrenoconiC0仃(phicho衄one(ACTH)Results：Compare

6、dwithnlecontrol目『oup，res咖inedrathadrelatiVelylonger1atencytime，tlleexploringbehaViorw嬲decreaLsed，觸dtimesofdefecationwasincreasedhlKddenplatf0冊(cè)仃ainingofMorTisw砷ermaze，themeanescapel砷e11cyoft11emiceinmeChronicrestraintgrou

7、pswerelongerth鋤thatofthecon仃Dlrat11lspatialprobetests，theaVerageperc既tagesoftlleSwi瑚mingtimeillmeplatfomquad船ntinmerestraint伊oupratwerelessmanthoseill廿lecontrolgroupTheseresultShowmatchrollicpsycholo百calsn髑smayresultinan

8、xie魄dep喲ssion，ilIlpairsmeco鰣tiVcfiln“oniIlmiceIIlsllspelldtailtest蒯nedlIlicehadrelatiVelylongerstayingtimesThesefindingsuggeSttllatCtI枷cpsycholo百calstre鸛剛diIlduced刪sionC吶Ilics仃懿ssignificantlysuppressedbodyweigbtgainSplee

9、ni11dex，nleweiglltofmeseIlt耐clyIIlphocytenode’mIen嘶berofsIllallintes廿nalppnodede∞淞edsigni丘caIlnyaRerc_111oIlicps)rcholo百cals仃Iess，whercasThymusindexdid110tc：hangesi鰣丘cantlyThel鉀elofint甜eu_kin1aIldint甜eul(in2iIlthes仃粥sgro

10、upweremaddylowertllaIlmatincont】的lgroupCl啪Ilics仃esssi嘶6caIltlydecreasedlevelsofI【廣1andIL2Compairedwitlltllecontmlgroup，t11esemmcontentsofcortiC0steroneinmes協(xié)ess掣0upwereSigmficantlyhigh既TheseresultiIldicatedthatchroIlicps