氯霉素在聚氧乙烯型非離子表面活性劑-水體系中穩(wěn)定性研究.pdf

1、浙江大學碩士學位論文氯霉素在聚氧乙烯型非離子表面活性劑水體系中穩(wěn)定性研究姓名：張麗霞申請學位級別：碩士專業(yè)：化學工程指導教師：陳志榮201101浙江大學碩士學位論文ABSTRACTABSTRACTThechloramphenicoleyedropsarewidelyusedandhavea‘broadmarketprospectHoweverthechloramphenicolisunstableandhydrolyzeseasilyi

2、naqueoussolutionItisofgreatimportancetoimprovethestabilityofchloramphenicolinaqueoussolutionTheGaussianwasusedforthegeometricconfigurationoptimizationandchargedistributionanalysisofchloramphenic01Thereasonthatthechloramp

3、henicolhydrolyzeseasilywasgotThehydrolysiskineticsofchloramphenicolWasdiscussedandthehydrolytickineticequationwasabtainedItwasfoundthattherateofhydrolysisWastwice、)l，itll7℃increasingofthetemperature，whichindicatedthehydr

4、olysisWassensitive謝t11temperature1HNMRWasusedtostudythesolubilizationpositionofchloramphenicolinthepolyoxyethylatednonionicsurfactantrnicelleandtheexitingformsofsmallamountofwaterinthesurfactantThechioramphcnicolwasorien

5、tationarrangedinthesurfactantmicelleThehydrophobicgroupofchloramphenicolwassolubilizedinthepalisadelayerofthemicellewhilethehydrophilicgroupinthehydrophilicshellswhichwerecomposedofmanyoxyethylenegroupsThereversemicellef

6、ormedinTween80andAEO10systemsrespectively、Ⅳinl28percentofwaterinmassfractionbutdidnotintheTX13andEL10systemswiththeadditionofwaterThestabilityofchloramphenicolWasstudiedindifferentpolyoxyethylatednonionicsurfactantwaters

7、ystemsThechloramphenicolpartitionedbetweentheaqueousphaseandthemicellarphaseThehydrolysisbehaviorofchloramphenicolintheaquousphaseWasstudiedbyhydrolyzinginbuffersolutionwhileinthemicellarphaseWasstudiedbyhydrolyzinginthe

8、systemcomposedofsurfactantandsmallamountofwaterTheresultsindicatedthatpolyoxyethylatednonionicsurfactantsplayedstabilizationeffecton、chloramphenic01ThehydrolysisrateconstantinmicellarphaseWasonly1／10～1／50ofthatintheaqueo