改性瓜環(huán)——甲基取代瓜環(huán)的合成、分離及其性質(zhì)研究.pdf

1、貴州大學(xué)碩士學(xué)位論文改性瓜環(huán)——甲基取代瓜環(huán)的合成、分離及其性質(zhì)研究姓名：李國平申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：應(yīng)用化學(xué)指導(dǎo)教師：陶朱20060501貴州大學(xué)碰士學(xué)位論文改性瓜環(huán)～甲基取代瓜環(huán)的合成、分離蕊其性質(zhì)研究Abstrac括Cucurbit[n]urilhasbeenallimportantpartofsupermoleculefieldintheseyearsThecucurbiturilsarepotentiallyasuseful

2、aswell—knownhostmoleculessuchascrownethers，cyclodextrins(CDS)Theirhost—guestchemistryaswellassupramolecularassembliesbasedonQfnlhasbeenstudiedandsummarizedinatopicalreviewarticleHowevefthepoorsolubilityincommonsolventsha

3、slimiteddevelopmentofthechemistryofcucurbit[n]uril。Thus，synthesisofQ[nlderivativesthatallowthemtodissolveinbothaqueoussystemsandcommonorganicsolvents，havereceivedgreatestattentionRecentlyanumberoffullyandpartiallysubstit

4、utedQ￡嬲havebeenreportedTheseincludethefullysubstituted(cyclohexano，CyH)(CyH)2Q[Sland(CyH)2Q【6】，Mel2Q[6】and(HO)2。Q[nlandthepartiallysubstitutedPh2Q[6]、Me6Q[6]、Me4Q[6]and(Me2CyP)nQf6】Wereportthesynthesisofaseriesofcucurbit

5、一tetrasubstitutedcucurbit[6](TMeQ【6】)，disubstitutedeucurbit[5](DMeQ[5])，hexasubstitutedcucurbit【5】(HMeQ[5])andsubstitutedcucurbit[7](MenQ【7】)byusingthedietherofdimethylglycolurilanddimmerofglycolurilinthis啦esisThisseries

6、ofsubstitutedcucurbit[翻h(huán)avebeendeterminedby1壬差NMRspectroscopyandES轟lS。AndtheparticularellipticalstructureofTMeQ[61hasbeenfurtherconfirmedbysinglecrystalX—raydiffractionTMeQ[6]、DMeQl51、HMeQ[5]andMenQ【7】showedsurprisingwat

7、ersolubilitywhichallowed娃stoinvestigatethepropertiesinneutralwarelSomesubstitutedMethylcucurbit[5]urilshavebeensyntesisedandisolated，theyarecharacterizedby1HNMRspectroscopymassspectraandsinglecrystalX—raydiffractionanaly

8、sisExperimentalresultsrevealthatthestructureof譙eQ籜lsinfluenceontheirsolubilityandwhichisrelatedwithdipolemomentfromchemicalcalculation。ThesolubilitYisMe6Qf5pMe2Q【5】Mel0Q【5】Q[51Andthenselectedconlnlonmetalionsandbenzimida

9、zolederiVativesastIletitlegueststodiscusstheinteractionmechanismbetweencucurbitandguestandthestructuresoftheselfassemblingmolecularcomplexbyusingX—raydiffractionanalysis，NMRteehniques。UVvisSpectroscopeandFluorescenceSpec

10、troscopeX—raydiffractionanal。ysisshowsthewholestructureofthecrystalcontainsacomplicatedsystemofhydrogenbondsincludingallstructuralunitsofthecrystal。lfomittingallhydrogenbondsandstrontiumiOIlS。a“moleculartube”andmolecular