基于玉米蛋白的靜電紡絲研究.pdf

1、東南大學碩士學位論文基于玉米蛋白的靜電紡絲研究姓名：宋唐英申請學位級別：碩士專業(yè)：生物材料與組織工程指導教師：李新松20080401AbstractAbstractElectrospirmingisartefficienttechniqueforthefabricationofpolymernanofibersElectrospunnanofibershavewideapplicationsinthebiomedicalmaterial

2、fieldssuchasdrugdelivery，wounddressingandtissueengineeringZeinisapromisingnaturalpolymerwithgoodbiocompatibityInthispaper，zein，zeinchitosanandzeinsilkelectrospunnanofibersWeresuccessfullyproduced，andtheirpropertieswerein

3、vestigated，includingmorphology，secondarystructure，mechanicalproperties，surfacehydrophilicproperties，invitrodegradationandcellcompatibilityZein，zeinchitosanandzeinsilkelectrospunnanofiberswereelectrospunfromtheiraqueouset

4、hanol，aceticacidformicacidandN，Ndimethylformamide(DMF)solutionsEffectsofthesolutionproperties(viscosity，conductivityandsurfacetension)andprocessparameters(voltage，distancebetweenthetipt0thecollectorandthesolutiondelivery

5、rate)wereinvestigatedonthefibermorphologyandtensilestrengthTheresultsshowedthatthediametersofribbonlikezeinnanofiberselectrospunfromaqueousethanolsolutionswerelargerthanthoseofroundnanofiberselectrospunfromacidorDMFsolut

6、ionsThetensilestrengthofzeinnanofibermatselectrospunfromaqueousethanolsolutionwaslowerthanthatfromacidorDMFsolutionIncreasingthezeinconcerntrationinthezein—chitosanblendsincreasedthediameterofzeinchitosanelectrospunnanof

7、ibersIncreasingthesilkcontentinthezein—silkblendtendedtodecreasethediameterofelectrospunnanofibersZein—silkelectrosptmmatswiththehighesttensilestrengthof1593MPawereobtainedatthezein／silkweightratioof1／2WAXDandFTIRtestwer

8、eappliedtostudythestructureoftheelectrospunnanofibersaswellastheinteractionofthecomponentsintheblendnanofibersDSCTGAWasusedtoinvestigatethethermalpropertiesofelectrospunzeinandzeinblendnanofibersResultsindicatedthatphysi

9、calandchemicalpropertiesofzeinandzeinblendmembranesshowednosignificantdifferencebeforeandafterelectrospirmingprocessThesurfacehydrophilicpropertiesoftheelectrospunzeinandzeinblendnanofibermatswereevaluatedbywatercontacta

10、ngletestResultsshowedthatelectrospunzeinnanofiberswereveryhygroscopicandhydrophobicInvitrodegradationstudyofthezeinandzeinsilkblendelectrospunnanofibersrevealedthattheelectrospunnanofiberswithsmallerfiberdiameterdegraded

11、fasterThebehaviorofcelladhesionandproliferationwereinvestigated，basedontheMTTmethod，byculturingL929cellontheelectrospunzeinandzeinblendnanofibermatsAllelectrospunzeinnanofibersshowedgoodbiocompatibilityandnocytotoxicityI