π-氧化樟腦的合成研究.pdf

1、廣東工業(yè)大學碩士學位論文π氧化樟腦的合成研究姓名：黃順申請學位級別：碩士專業(yè)：化學工藝指導教師：鄧旭忠201205廣東工業(yè)大學碩士學位論文ABSTRACT71；一Oxocamphorisastrongheartmedicine，whichcanbeusedincureofthecentralrespiratorydifficulty，circulationfailureandallkindsofdiseaseofaweakheartan

2、dbreathingdifficultiesItCanenhanceforceofcardiacmusclesystoleandimprovethefunctionofdiastolicfunction，especiallysuitablepediatricpneumoniaandheartfailurepatientswhoisvasomotionfunctionsarenotwellInthispaper，thepreparatio

3、nmethodsof兀oxocamphorweresummarizedand兀一oxocamphorWasfinallysynthesizedfromsourceextensive()camphorbytwicebromination，reduction，hydrolysisesterificationandoxidationreactionOptimumconditionsofintermediatesandtargetproduct

4、wereobtainedasfollows：(1)Thesynthesisof()一a—bromocamphor：，z(()一camphor)：n(bromine)=1：14，glacialaceticacidassolvent，reactiontimeWas6hat80“(2，theyieldof()一abromocamphorwas885％(2)Thesynthesisof()一7[bromocamphor：，z(()c【bromo

5、camphor)：n(bromine)=1：11，chlorosulfonicacidasanadjuvant，reactiontimewas2hatroomtemperature，theyieldof㈩cc，7[dibromocamphorwas801％；刀(㈩a，7【dibromocamphor)：n(zinc)=1：3，glacialaceticacidassolvent，icebathresponsewith3h，theyiel

6、dof()一兀一bromocamphorwas663％(3)Thesynthesisof()兀hydroxylcamphor：刀(()7c—bromocamph)：n(potassiumacetate)=1：15，glacialaceticacidassolvent，esterificationreactiontimewas30hat190℃Thenremovedthesolvent，andreactedattherefluxtempe

7、ratureinthehydrolysate(V(CH3CH20H)：V(w=55％potassiumhydroxide)=1：9)about25htogivethe()一xhydroxylcamphorinabout781％yield(4)Thesynthesisofx—oxocamphor：Choosechlorinepyridinechromiumacidsalt(PCC)asoxygenant，n(PCC)：刀(()一79hyd

8、roxylcamphoO=2：1，CH2C12assolvent，withnitrogenprotectionreacted2hunderroomtemperature，theyieldofT[oxocamphorWas955％ThestructureoftheintermediatesandtargetproductswasconfirmedbyⅡ乙GCMSand1HNMILTheexperimentalresultsshowedth