Pre-procedural atrial premature beats to predict late recurrence following radiofrequency catheter ablation for non-valvular pa.pdf

1、Background: Prediction of atrial fibrillation (AF) recurrence after radiofrequency ablation (RFA) based on pre-procedural factors allows better patient selection, superior counseling and individualized ablation planning.

2、 We hypothesized pre-procedural APB count could accurately predict late recurrence of AF (LRAF) after RFA.
　　Methods:140 PAF patients (43％females) undergoing first RFA from 2013.01.01 to 2015.01.31 were included. APBs

3、 and its indices were analyzed from 24-hour Holter recording performed within 1 week of RFA. Recurrence was noted at 3 and 12 months. Patients were categorized into LRAF and non-LRAF groups and independent associations c

4、omputed using x2 test and t-test where appropriate. Individual prediction ability was calculated using univariate logistic regression and statistically significant variables were incorporated into multivariate regression

5、 model. Subgroup analysis among 120 patients with APBs was computed to estimate if ABP count and its’ indices could predict ERAF and LRAF.
　　Results: 85.5% LRAF subjects had APBs (mean: 1531±3720/day), whereas 86% NLR

6、AF subjects had APBs (mean: 4370±9915/day). 44%(18/48) in LRAF group had polymorphic APBs (PmAPB) opposed to a higher 63.3% (50/92) in NLRAF group. Only APB count and PmAPB revealed independent association with LRAF (p=0

7、.056 and p=0.042) but not ERAF among 120 patients with APBs. In this subset of patients, APB count negatively predicted LRAF (95% CI=0.69-0.98, P=0.025) and PmAPB positively predicted LRAF (95%CI=0.211-0.978, P=0.042) bu

8、t not ERAF in univariate analysis and only PmAPB predicted LRAF in multivariate analysis.
　　Conclusion: In PAF patients undergoing RFA, presence of pre-procedural APB is not a risk factor for LRAF. APB count in fact i