PMBP席夫堿配體及配合物的合成、晶體結(jié)構(gòu)研究、生物活性測定和量子化學(xué)計(jì)算.pdf

1、天津師范大學(xué)碩士學(xué)位論文PMBP席夫堿配體及配合物的合成、晶體結(jié)構(gòu)研究、生物活性測定和量子化學(xué)計(jì)算姓名：楊云申請學(xué)位級別：碩士專業(yè)：物理化學(xué)指導(dǎo)教師：王瑾玲繆方明2002.4.1AbstractSinceSchiffbasecompoundsareeasytoprepareandhavehighbiologicalactivity，theresearchofSchiffbasesisstilloneofthecentralissuesi

2、nthecoordinationchemistrybiomedicineandpharamaceuticalchemistryfieldInaddition，recentresearchesmanifestedthatSchiffbasecompoundswillprobablybecomethenewtasksofmaterialchemistryInthisthesis，wereportthesynthesisof14kindsof

3、complexesofmetalnitratewithSchiffbasesderivedfrom1benyl一3一methyl4benzoyl—pyrazolin5一oneand(ochloro，m—chloro，P—chloro，24一dichloro)aniline，4aminoantipyrine，characterizedbyIRUvTGDTA，andelementalanalysisThetwocrystalstructur

4、eanalysisofSchiffbaseligandsderivedfromlbenyl3methyl4一benzoylpyrazolin一5oneandm—chloroaniline4aminoantipyrinebyXraydiffra一ctionmethodindicatesthattheyareneutraldentatesinenamineketoformButwhentheycoordinatedwithmetal，the

5、ywillloseoneprotonandbecometoonevalentnegativeligand，provedbythecrystalstructureofCo斗complexesderivedfromthe1benyl一3methyl，4benzoyl——pyrazolin5oneandmchloroanilineSchiffbasewhichdeterminedbyUSTheantibacterialactivityofSc

6、hiffbasecompoundsatdifferentconcentrationsagainstEColiandSauresaredeterminedTheresultsindicatematalmostallcompoundshavetheactivityofinhibitingthegrowthoftwobacteriaAlso，somecomplexesmayinhibittheformationofO2‘Usingquantu

7、mchemistrymethodperformsthecalculationsofthreecrystalstructuresWediscussthereactionmechanismofSchiffbaseformationTherelationshipbetweenstructureandactivityisalsodiscussed，offeringimportanttheorybasisforfutureresearchesKe