紅斑狼瘡課件

1、,2016年,,,,Lupus erythematosus,,Here is one piece of picture with the symptom of skin.,,,,,,2016年,,Brief Introduction and etiopathogenesis(發(fā)病機理),01,02,03,CONTENT,Clinical symptoms (臨床癥狀）,The latest research progress,Trea

2、tment and prevention of lupus erythematosus,LE,6年,04,1,,,,,,,,,,,,,,Brief Introduction and etiopathogenesis(發(fā)病機理),,1,,,,,,,,,,,,Brief Introduction,Autoimmune disease(AID)Damage multiple systems with multiple organs

3、involvedComplex clinical manifestationsLong durationSkin manifestationsThe majority of the patients are female.,,2,3,4,1,5,Pathology（病理）,Pathological morphology varies depending on the condition, location, large chan

4、ges.There are several common types.,Vascular lesions form of necrotizing vasculitis of small vessels, including small arteries or arterioles.,Patients with kidney disease will also have diaease of the renal glomerulus

5、and renal tubules and interstitial and blood vessels.,Cardiac abnormalities including pericarditis, myocarditis, heart valves and endocardial disease.,Pathological changes of skin including epidermal（表皮的） atrophy（萎縮）, ne

6、crosis（壞死） of the skin ulcers（潰瘍） and edema（水腫）.,Diffuse lesions(彌漫性病變) of the nervous system consist of fewer nerve cells, small vessel vasculitis, small infarction（梗塞）, necrosis and hemorrhage（出血）.,Pathogeny（病因）,The ex

7、act cause of Lupus Erythematosus has not been found, which is the same as other autoimmune diseases. Environmental pollution can also cause this diaease which should be pay attention to.,Genetic factors,Infection facto

8、rs,Endocrine factors,Environmental factors,Other factors,2,,,,,,,,,,,,,,,,,,,,,Clinical symptoms and detection methods,clinical symptoms,3,6,4,Raynaud's phenomenon(雷諾現(xiàn)象）,Dermal pathology（皮膚病理）,5,1,9,2,Blood disor

9、der(血液病變）,Organ damage,Lymphatic system,Fever,8,7,Arthritis(關(guān)節(jié)炎）,Oral or nasal pharyngeal ulcer,Infection（傳染性）,clinical symptoms,01,Dermal pathology皮膚病理,Facial butterfly erythema（面部蝶形紅斑）； disc erythema（ 盤形紅斑）；dermati

10、tis cause hair loss,Renault phenomenon is a loop around the disease. Under the stimulation such as cold or emotional tension, suddenly occurred in refers to small artery spasm.,Raynaud's phenomenon(雷諾現(xiàn)象）,Blood disord

11、er(血液病變）,All kinds of blood cells are reducing,additionnally,patients may suffer from vasculitis,04,Organ damage,Patients may suffer from heart damage, lung damage, brain damage, gastrointestinal damage（消化道損害）, with lupu

12、s nephritis（狼瘡性腎炎） and eye lesions,clinical symptoms,05,Lymphatic system,About 50% of SLE patients with local or systemic lymph node enlargement,in neck, armpits, jaws swelling ，which are soft and no tenderness.,Patient

13、s tend to be immunologic dysfunction,whose body can produce many kinds of substances, as a heat source and make the body heat.,Fever,Arthritis(關(guān)節(jié)炎）,08,Oral or nasal pharyngeal ulcer(口腔及鼻咽部潰瘍）,clinical symptoms,9,,Infec

14、tion（傳染性）？？？,Although the incidence of sle is far higher in our country than western countries, comparing with other common diseases is very rare. Because the patient is relatively small, a lot of people don't know

15、much about this disease.when they see this disease ,they will want to know whether it is infectious？ The answer is no, sle will not spread by one person to another person. There are many factors occurring to reduce the b

16、ody's immune tolerance, making the body's immune function disorder.Patients with the disease in the plateau can work, study, and participate in the activities of society like the normal,3,,,,,,,,,,,,,,,,,,,,,,,,

17、,Treatment and prevention of lupus erythematosus,LE,,Treament,SLE系統(tǒng)性紅斑狼瘡,CLE,n,,,,,,,皮膚型紅斑狼瘡,,,,,,紅蝴蝶瘡,,,In principle, CLE does not use hormones （激素） anti malaria drugs as the first choice.,,Those who has light symp

18、tom--- only mild rash, arthritis, pleurisy, don’t need hormene,,,CorticosteroidsCTLImmunoadsorption therapy,1.Hormone therapy,.,2.The psychological therapy of SLEThe therapy includes “ revisiting ”---help them lesse

19、n the intensity of emotion,,,prevention,.,1 Removal of possible incentivesuse medicine of SLE prudently； Avoid exposing to sun chronically （ use anti light agent ）2  Keep optimistic3 contraception （

20、節(jié)育）If the patient have conceived,she had better do the treatment of abortion4  early diagnosis,4,,,,,,,,,,,,,,,,,,,,,,,,,,The latest research progress,,,.,,1.Artemisinin can treat lupus (SLE),SM934（水溶性青蒿素衍生物） is

21、proved to be able to treat SLE,2. classification of CLE and the diagnosedirect immunofluorescence and photoprovocation may be applied to confirm the diagnosis in specific cases.A revised scoring system, the Cutaneous L