兒童期創(chuàng)傷對抑郁癥患者糖皮質激素受體1F啟動子區(qū)域CpG島DNA甲基化狀態(tài)的影響.pdf

1、中圖分類號R2壘窆UDC610碩士學位論文學校代碼!Q三蛩密級公開ChildhoodtraumainvolvingGlucocorticoidReceptorGeneExon1FonCpGislandsundergoingDNAmethylationinDepression兒童期創(chuàng)傷對抑郁癥患者糖皮質激素受體1F啟動子區(qū)域CpG島DNA甲基化狀態(tài)的影響作者姓名：王思(SeewoobudulVasish)學科專業(yè)：臨床醫(yī)學研究方向：精神病

2、與精神衛(wèi)生學學院(系、所)：湘雅二醫(yī)院指導教師：李凌江教授論文答辯日期矽f諱二≮答辯委員會主席中南大學二。一三年五月ChildhoodtraumainvolvingGlucocorticoidReceptorGeneExonIFonCpGislandsundergoingDNAmethylationinDepressionAbstractBackgroundMajordepressiontoday，accountsastheleadin

3、gcauseofdisabilityinthewholeworldaffectingpeopleofallagesManyyearsofresearchonanimalmodelsandhumanmodelshavedocumentedtheimpactofearlychildhoodexperiencesontheneurobiologicalmechanismaffectingthepsychopathologyoflateadul

4、tlifeChildrenaredependentonthecaregiversandparentsfortheirbasicneedssuchasphysical，socialandemotionalneedsEventually，thesechildrenundergosubstantialdevelopmentalchangesintheirneuralpathwaysthatdetermineemotionsandbehavio

5、urThehypothalamus—pituitary—adrenal(HPA)axisplaysafflajorroleintheregulationofthestressresponsesofthehumanbodyHoweverchangesoccurringtotheHPAaxismaygiverisetostressandrisksforpsychiatricdisordersTakingintoconsiderationth

6、emultiplepromotersoftheGR，thepromoter1FintheCpGislandsismorepronetomethylationduetoearlylifeexperiencesThisstudyexaminesthestatusofDNAmethylationoccurringintheCpGislandsoftheGRpromoterregion1Findepressedpatientswithchild

7、hoodtraumainChinaMethodsInordertoavoidanybiasandensurethereliabilityandvalidityofthisstudy，variablesusedformeasuringchildhoodtraumaandmajordepressionwererelativelyadaptedtotheChinesecultureandthesamplingdesignwasalsomade