用于宮頸癌早期診斷的近紅外漫射光頻域外差檢測系統(tǒng).pdf

1、天津大學(xué)碩士學(xué)位論文用于宮頸癌早期診斷的近紅外漫射光頻域外差檢測系統(tǒng)姓名：馬潔榮申請學(xué)位級別：碩士專業(yè)：生物醫(yī)學(xué)工程指導(dǎo)教師：趙會(huì)娟20090801ABSTRACTBecauseofthehighincidenceandyoungertrend，thecervicalcancerbecomesaseriousthreattowomen’ShealthItiSfoundthatthecurerateofcervicalcancerdepe

2、ndsontheearlydiagnosisSodevelopingaconvenientandrapiddiagnosisisverycrucialfortheearlydiagnosisandtreatmentofcervicalcancelRecentlythenearinfrareddiffusereflectancedetectiontechniquesbecameafocusofearlycervicalcancerdiag

3、nosis，becauseithastheadvantagesofdeeppenetration，non—invasive，anddirectreflectionofphysiologicalchangesinorganizationsInthethesis，basedonthetheoryofthefrequency—domainmethod，thenearinfrareddiffusereflectancemeasuringsyst

4、emthatappliedhighfrequencymodulationandheterodynedetectionmethodWaSsetupAsahighfrequencymodulatedsourceilluminedthetissue，thediffusereflectance(especiallyforthemodulationandphasedelay)wasrecordedThefrequencydomaindiffuse

5、reflectancemeaSuringsystemincludesahigh—frequency(1OOMHz)modulatedlaser(780am)lasersource，photomultipliertube(PMT)，theheterodynedetectioncircuithighspeeddataacquisitionunit，dataacquisitionsoftware，andinversealgorithmnefa

6、ctorsthatinfluencetheaccuracyofsystemwerecarefullyresearched，whiletheaccuracyofthesystemwastestedTheresultsindicatedthatthedeviationofthemodulationandphasedelaywerebothlessthan2％Thenthephantomswithcertainopticalpropertie

7、sweremeasured111emeasurementofmodulationandphasedelaywereappliedtodeterminethetissueopticalpropertiesofsamples，especiallyforabsorptioncoefficientandreducedscatteringcoefficientbyusingartificialneuralnetworksneresultsindi

8、catedthatthedeviationofabsorptionandscatteringcoefficientwerewithintherangeof10％and2％respectivelyThetissueopticalpropertieswhichprovidethephysiologicalinformationwillbeveryusefultotheearlydiagnosisofcervicalCanCerKeyword