（R）-DAIPEN的合成及分析表征.pdf

1、浙江大學理學院碩士學位論文（R）DAIPEN的合成及分析表征姓名：李烽俊申請學位級別：碩士專業(yè)：化學指導教師：吳天星商志才20060301浙江大學碩士學位論文Abstract(R)DAIPENwaspreparedstartingfromDvalineThecrucialstepsinthesynthesiswerefoundasfollows：firstlyD—valine／dichloridesulfoxide=l：12(moler

2、atio)，reactiontemperature：roomtemperature，reactiontimelh；andthenrcfluxingfor3hThesolventwasremovedinarotaryevaporatorandthesolidcanbeusedtonextreactionwithoutreerystallization；inthesecondstep，俾)methyl2一amino3methyl—butan

3、oatehydrochlOride，pmethoxypenylmagnesiumbromide=1：6，reactiontemperature：loomtemperature，reactiontime：24h，afterremovingthesolventtheresultingslurrywascrystallized毓etherandreerystallizedfromethylacetate；inthethirdstep，(胄)一

4、2aminol，lbis(4methoxyphenyl)一3methylbutan一1一ol／CbzCl／NaOH=1：3：4，reactionatroomtemperaturefor4hReerystallizationofsamplesfromester：ethanol=20：Igivesthepoursolid；inthefourthstep，體)benzyl1hydroxy11bis(4methoxyphenyl)一3一meth

5、ylbutan2ylcarbamate／NaN3仉^=1：2：5，reactionat0“Cfor4handthenatroomtemperaturefor12hafterremovingthesolventtheresultingslurrycanbcusedtonextreactionwithoutrecrystallization；inthelaststep，hydrogenationatroomtemperaturefor24h