蒽環(huán)類藥物治療非霍奇金淋巴瘤心臟毒性的臨床研究.pdf

1、天津醫(yī)科大學(xué)碩士學(xué)位論文蒽環(huán)類藥物治療非霍奇金淋巴瘤心臟毒性的臨床研究姓名：邵維維申請學(xué)位級別：碩士專業(yè)：內(nèi)科學(xué)血液病指導(dǎo)教師：邵宗鴻20090501天津醫(yī)科大學(xué)碩士學(xué)位論文AbstractPurpose：Toanalyzetheclinicalfeaturesofcardiotoxicityandthecorrelationfactorsofcardiotoxicityinducedaftertreatmentwithanthracy

2、clinesfornon—Hodgkin’SlymphomaMethods：Theclinicalfeaturesof94patientswithnon—Hodgkin’SlyrnphomawereretrospectivelyanalyzedTheclinicalsymptomsandobjectiveexaminationindicators，suchastheelectrocardiogram，myocardialenzymes，

3、cardiactroponinT，andcardiacultrasoundresultsofthepatientsbeforeandafterchemotherapywerecomparedThecorrelationbetweenthehappeningofcardiotoxicityandthefactorsofaccumulateddose，thepatient’Sage，sex，pasthistoryofcardiovascul

4、arlymphomatypeandstage，theexistenceofchromosomalabnormalities，thedegreeofanemiahepaticandrenalfunction，LDH，theuseofEPOandtheprotectivetreatmentofcardiacetcwerestudiedThecorrelationriskfactorsofcardiotoxicityinducedaftert

5、reatmentwithanthracyclinesfornon—Hodgkin’SlymphomawereanalyzedbytheregressionanalysisResults：Ofa11the94patients，theincidencerateofcardiotoxicitywas202％160％wasacuteorsubacutecardiotoxicity42％WaschromccardiotoxicityThemedi

6、anaccumulatedanthracyclinedosewere1429mg／m2，themediancoursesoftreatmentweresix，themediantimewere34weekswhentheydevelopedcardiotoxicityThedifferencebetweencardiotoxicityinducedbyaccumulatedanthracyclinedosewassignificant(

7、P=0001)，andtherewasapositivecorrelation(r=0443，P=0000)betweenthemThereWasapositivecorrelationbetweencardiotoxicityandthepatients’ageTheincidenceofcardiotoxicitywashigherintheover55yearoldagegroupTherewasacorrelationbetwe

8、encardiotoxicityandsexTheriskofcardiotoxicityoffemalepatientsbelow55yearoldagegroupwashigherTherewasnocorrelationbetweencardiotoxicityandthehistoryofangiocardiopathythetypeandstagingoflymphoma，thechromosomalabnormalityth