近紅外無創(chuàng)血糖測量——基于P3和漫射近似的浮動基準(zhǔn)點(diǎn)的理論研究.pdf

1、天津大學(xué)碩士學(xué)位論文近紅外無創(chuàng)血糖測量——基于P3和漫射近似的浮動基準(zhǔn)點(diǎn)的理論研究姓名：史振志申請學(xué)位級別：碩士專業(yè)：生物醫(yī)學(xué)工程指導(dǎo)教師：徐可欣20090801ABSTRACTNoninvasivesensingofhumanbloodglucoseconcentrationwithnearinfraredspectroscopyiSaninternationalfrontiertopicwhichdoesnotcomeintocli

2、nicalrealizationThemainproblemiscausedbyboththevariablehumanphysiologyandoutsideinterferenceduringtheprocessofmeasurementwhichleadtoapoorprecisionintheclinicalbloodglucosesensingAccordingtothisproblem，ourgroupproposedafl

3、oatingreferencemethodologyThispaperdevelopsintermofthefloatingreferencemethodology，andstudiestheexistenceoffloatingreferencepointduetothreeaspectsoftheory，simulationandexperimentsAndtheapplicabilityoftheoreticalmodelsbui

4、ltbythediffusionandP3approximationareanalyzedforthecalculationoffloatingreferencepointFirstofall，thispaperintroducesthephotonpropagationmodelinbiologicaltissue，andanalyzestheMonteCarlosimulationbasedonfiberreceiverandfib

5、er1aunchAccordingtOtheMiescatteringtheory，wedevelopaMiescatteringprocedureforcalculatingtissueopticalparameters，inordertoinvestigatetheinfluenceofglucoseconcentrationontheopticalparametersBasedonthediffusionandP3approxim

6、ation，wehaveestablishedtheexpressionofthediffusereflectionrateagainstwiththeglucoseconcentrationsensitivityontheconditionofasinglepointsourceandsemiinfiniteextrapolationboundaryAconclusionthatthesensitivityofabsorptionco

7、efficientandscatteringcoefficientaredominantinthetotalsensitivityismadetOtestifytheexistenceoffloatingreferenceposition，andgiveacertainamountofvariationintheory，throughtheanalysisofdiffusereflectionrateontheopticalparame

8、tersensitivity，combiningtheinfluenceofglucoseconcentrationontheopticalparametersAndmore，thepaperstudiestheexistenceoffloatingreferencepointandtheapplicabilityoftheoreticalmodels，bythesampleofintralipidsolutionThestudiess

9、howthatthefloatingreferencepointexists，andtheresultsofdiffusionandP3approximationareclosetothesimulationintherelativelylargescatteringcoefficientBesides，whenthereducedalbedo(a)islargerthan093，thediffuseapproximationresul