老化對貓不同視覺區(qū)域細(xì)胞的潛伏期和變異性的影響.pdf

1、中國科學(xué)技術(shù)大學(xué)碩士學(xué)位論文老化對貓不同視覺區(qū)域細(xì)胞的潛伏期和變異性的影響姓名：譚佳博申請學(xué)位級別：碩士專業(yè)：神經(jīng)生物學(xué)指導(dǎo)教師：周逸峰201110ABSTRACTABSTRACTDuringnormalaging，visualabilitiesareimpairedaSaresultThiskindoffunctionalimpairmentcannotbesimplycontributedtothechangesintheoptic

2、alsystemofeyesInstead，moreandmorediscoverieshaveprovedthatthedegradationofvisualnervesystemshouldberesponsibleforthisphenomenonIndifferentvisualareas，thedegradationofneuroncharactersisdifferentThereisahypothesissaysthatm

3、oreadvancedvisualcodexhurtmoreseriouslyduringaging，butitstillneedsfurtherevidencestosupportInthisresearch，weusetwoimportanttimecharacters，responselatencyandvariabilitytoevaluatethedegenerationofvisualcharactersBasedonthi

4、sresearch，wetrytoverifythehypothesismentionedaboveandprovidesupportsforthedegradationofadvancedvisualfunctionsInthisresearch，wecomparedvisualresponselatencyinLGN，V1，V2andPMLSinoldandyoungcatsWefoundthatthereisnosignifica

5、ntchangeoftheresponselatencyinLGNbetweenoldeatsandyoungcatsButintheotherthreeareas，oldcatsexhibitedsignificantlylongerresponselatencythanthoseinyoungcatsAndthiskindofprolongationWasmoresignificantinareawithhigherlevelinv

6、isualsystemThesefindingssuggestedthatagingwouldlengthenresponselatencyinvisualareasandmoreadvancedareaswereinfluencedmoreseriousWhat’Smore，theprolongationWaspassedonfromoneareatoanotheronewithhigherlevel，andthedamageswer

7、eaccumulatinginvisualpathwayTofurtherinvestigatetheinfluenceofagingonresponsevariabilitywecomparedresponsevariabilityinLGN，V1，V2andPMLSinoldandyoungcatsItshowedthattherewasnosignificantchangeoftheresponsevariabilityinLGN

8、betweenoldandyoungcatsButinotherthreeareas，responsevariabilitywasinfluenceddifferentlybyagingResponsevariabilitywasenlargedinoldcatsandmoreadvancedareasgotmoredamagesItisknownthatresponsevariabilitymightaffectlatencyinvi

9、sualpathwayTherefore，wefurtherstudiedthecorrelationbetweenincreasedresponsevariabilityandprolongedvisualresponselatencyOurstudyshowedthattherewasastrongcorrelationbetweenthesetwofactors，whichindicatedthecloseinnerrelatio