艾灸提高老年大鼠學(xué)習(xí)記憶能力的海馬神經(jīng)發(fā)生機制.pdf

1、成都中醫(yī)藥大學(xué)碩士學(xué)位論文艾灸提高老年大鼠學(xué)習(xí)記憶能力的海馬神經(jīng)發(fā)生機制姓名：陳利章申請學(xué)位級別：碩士專業(yè)：針炙推拿學(xué)指導(dǎo)教師：胡玲香2007成都中醫(yī)藥大學(xué)碩士畢業(yè)論文 6Abstract Objective To determine whether moxibustion therapy can improve learning & memory ability in aged rats, and enhance

2、hippocampal neurogenesis. Methods We take moxibustion therapy on acupoints “ Baihui” (DU20) and “ Mingmen” (DU4) for 6 courses treatments on SD aged rats. We use Morris water maze to evaluate learni

3、ng & memory ability. After i.p. BrdU into the body, we use fluorescentimmune labeled technology to observe hippocampal neurogenesis. Results Moxibustion therapy can improve learning & memory

4、 ability either in normal aged rats or in aged cognitive decline rats. Compared to normal aged rats group, more positive BrdU labeled neurons were expressed in hippocampus of normal aged rats treate

5、d by moxibustion(P<0.05). In aged cognitive decline rat group treated with moxibustion therapy, more positive BrdU labeled neurons expressed than those in the group without moxibustion treatment

6、 did(P<0.05). Conclusions Moxibustion therapy can improve learning and memory ability in both normal aged rats and cognitive decline rats which may be associated with hippocampal neurogenesis. Key