溫腎膠囊對抑郁模型大鼠行為、腦內神經遞質,血清T3、T4、TSH的影響.pdf

1、甘肅中醫(yī)學院碩士學位論文溫腎膠囊對抑郁模型大鼠行為、腦內神經遞質血清T3、T4、TSH的影響姓名：許立瑋申請學位級別：碩士專業(yè)：中西醫(yī)結合臨床指導教師：@201105溫腎膠囊對抑郁模型大鼠行為、腦內神經遞質，血清T3、T4、TSH的影響22AbstractObjective:Throughtheresearchonitseffectonbrainneurotransmitter（5HT、DA）serum（T3；T4；TSH）indepr

2、essionmodelratsthisstudyinvestigatesWenshenCapsule’santidepressantfunctionmechanism.Methods:Atotalof60Wistarratswereromlydividedintosixgroups:nmalcontrolgroupmodelgroupsmallmediumlargedoseofWenshengroupsPuyugroup.Exceptf

3、thenmalgrouptheothergroupswereexposedtothechronicmildunpredictedstressmodelf21days.Thentheyweretreatedcontinuouslyf21daysregularlycontrollingtherats’weightsugarconsumptionfcedswimmingimmobilitytimebehavialchangesevaluate

4、dtheconcentrationsof5HTDAintheirbraintheconcentrationofT3T4TSHintheirserum.Result：Comparedwiththenmalcontrolgroupthebodyweightofthemodelgroupratspedmovementreducedsugarconsumptionwerealsoreducednonswimmingtimeextended.Af

5、tertheratshadbeentreatedfdepressionwithWenshencapsuletheirbodyweightofincreasedmentalstatusimprovedmovementincreasedsugarconsumptionincreasedthefcedswimmingimmobilitytimeshtened.TheelevatedT4levelsweresignificantlyreduce

6、dthereducedT3levelsweresignificantlyincreasedtherebyreducingthedegreeofdepressionintherats.atthesametimethelargedoseofWenshencapsuleincreasedthelevelof5HTDAinthedepressionmodelgroupwhencomparingthiswiththemodelgroupithas

7、statisticalmeaning.Conclusion:ThemechanismofWSJNantidepressantfunctionmightpossiblyberelatedtotheadjustmentofthyroxineleveltotheinhibityneurotransmitters.thisprovideduswithanimptantexperimentalfoundationfusingWenshencaps

8、uleasclinicaltreatmentfdepression.HoweversincethefunctionmechanismofChineseherbalmedicineiscomplexitsantidepressantfunctionmightbetheresultofmultitargetcombinedeffectthatwhenusingWSJNtotreatdepressionitmightoperatethroug